A new vaccine to improve tuberculosis prevention
A STINGing vaccine for TB
This study is testing a new version of the BCG vaccine to see if it can better protect against tuberculosis and possibly help treat bladder cancer, and they’re looking for patients to join the trials to help find out how safe and effective it is.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10841675 on NIH RePORTER |
What this research studies
This research focuses on developing a modified version of the Bacille Calmette–Guérin (BCG) vaccine to enhance its effectiveness against tuberculosis (TB). The new vaccine, called BCG-disA-OE, is engineered to stimulate a stronger immune response and has shown promising results in animal models. By administering this vaccine through different routes, the researchers aim to improve protection against TB and also explore its potential use in treating non-muscle invasive bladder cancer. Patients may be involved in trials to assess the vaccine's safety and efficacy.
Who could benefit from this research
Good fit: Ideal candidates for participation would include adults over 21 years old who are at risk for tuberculosis or have non-muscle invasive bladder cancer.
Not a fit: Patients who are not at risk for tuberculosis or do not have bladder cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a more effective vaccine that significantly reduces the incidence of tuberculosis and improves treatment options for bladder cancer.
How similar studies have performed: Other studies have shown promise in modifying BCG for improved efficacy, indicating that this approach has potential based on previous research.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Bishai, William Ramses — Johns Hopkins University
- Study coordinator: Bishai, William Ramses
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.