A new treatment to prevent infections after gastrointestinal surgeries
Official title: A novel, non-antibiotic, microbiome-directed agent to prevent post-surgical infection
Funded at Covira Surgical · NIH-11259999 · Data updated 2026-11-12
This study is testing a new oral treatment called CS-0003 to help prevent infections after gastrointestinal surgeries by supporting good bacteria in your gut while keeping harmful ones at bay, making it easier for patients to recover safely.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Covira Surgical NIH-funded |
| Lab location | 1 site (North Chicago, United States) |
| Project start | January 1, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $1,000,000 |
| NIH project number | 4R42AI174369-02 |
| Project ID | NIH-11259999 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients scheduled for gastrointestinal surgeries who are at risk of developing surgical site infections.
✕Less likely to help
Patients who are not undergoing gastrointestinal surgeries or those with existing severe infections may not benefit from this research.
What this research studies
This research focuses on developing a novel, non-antibiotic therapy called CS-0003 to prevent post-surgical infections in patients undergoing gastrointestinal surgeries. The approach aims to maintain the beneficial effects of the gut microbiota while suppressing harmful bacteria that can lead to infections. By providing a source of phosphate and a protective barrier against pathogens, this treatment seeks to reduce the incidence of surgical site infections, which are a significant concern for patients. The therapy is administered orally, making it a convenient option for patients recovering from surgery.
Why it matters
Potential benefit: If successful, this research could significantly reduce the risk of post-surgical infections, leading to better recovery outcomes for patients.
How similar studies have gone: While the approach of using a non-antibiotic therapy to manage infections is innovative, similar strategies targeting the microbiome have shown promise in other contexts, suggesting potential for success.
Where this research is happening
-
Covira Surgical
North Chicago, United States Active
Researchers
- Principal investigator: Hennessey, Patrick — Covira Surgical
- Study coordinator: Hennessey, Patrick
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.