A new treatment method for Alzheimer's Disease
Official title: A novel therapeutic approach for Alzheimer Disease (AD)
Funded at University of Missouri-Columbia · NIH-10740016 · Data updated 2026-11-12
This study is exploring a new way to help people with Alzheimer's by boosting a important substance in the body called NAD+, which might improve brain function and slow down memory loss, using a special method that involves your own blood cells.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $392,026 |
| NIH project number | 1R21AG080715-01A1 |
| Project ID | NIH-10740016 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's Disease who may benefit from enhanced metabolic function in the brain.
✕Less likely to help
Patients with advanced Alzheimer's Disease or those who do not have a diagnosis of Alzheimer's may not receive benefit from this research.
What this research studies
This research investigates a novel approach to treating Alzheimer's Disease by focusing on increasing levels of a crucial metabolite called NAD+ in the body. The study aims to use genetic interventions to enhance the production of NAD+ in red blood cells, which could help improve brain function and slow the progression of Alzheimer's. By using a specific type of virus to deliver genetic material to the patient's own blood stem cells, the researchers hope to create a sustained increase in NAD+ levels throughout the body. This innovative method could potentially provide a new way to combat the cognitive decline associated with Alzheimer's Disease.
Why it matters
Potential benefit: If successful, this research could lead to a new therapeutic option that slows down or improves cognitive decline in Alzheimer's patients.
How similar studies have gone: While the approach of using genetic interventions for NAD+ elevation is innovative, similar strategies targeting metabolic dysfunction in neurological disorders have shown promise in preliminary studies.
Where this research is happening
-
University of Missouri-Columbia
Columbia, United States Active
Researchers
- Principal investigator: Ding, Shinghua — University of Missouri-Columbia
- Study coordinator: Ding, Shinghua
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.