A new treatment for poisoning from organophosphate chemicals
Official title: A Vitamin K analog countermeasure for organophosphate poisoning
Funded at Neuroene Therapeutics INC · NIH-10843945 · Data updated 2026-11-12
This study is working on new Vitamin K-like medicines that could help people who have seizures from organophosphate poisoning, which can happen from certain pesticides or chemical attacks, and aims to find quick relief for those affected.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Neuroene Therapeutics INC NIH-funded |
| Lab location | 1 site (Washington, UNITED STATES) |
| Project start | May 18, 2023 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $299,713 |
| NIH project number | 5R43AI176434-02 |
| Project ID | NIH-10843945 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have been exposed to organophosphate chemicals or suffer from pharmacoresistant seizures.
✕Less likely to help
Patients who do not have a history of organophosphate exposure or do not experience seizures may not benefit from this research.
What this research studies
This research focuses on developing a novel class of Vitamin K analogs that can counteract the effects of organophosphate poisoning, which is a serious health threat due to its use in chemical warfare and as pesticides. The approach involves creating compounds that penetrate the brain effectively and provide rapid relief from seizures caused by these toxins. The research utilizes animal models to test the efficacy of these compounds in treating pharmacoresistant seizures and protecting mitochondrial health. If successful, these treatments could be stockpiled for use in public health emergencies.
Why it matters
Potential benefit: If successful, this research could provide a fast-acting and effective treatment for patients suffering from organophosphate poisoning and related neurological conditions.
How similar studies have gone: While there are existing treatments for organophosphate poisoning, this approach using Vitamin K analogs is novel and has not been extensively tested in clinical settings.
Where this research is happening
-
Neuroene Therapeutics INC
Washington, United States Active
Researchers
- Principal investigator: Chan, Sherine S — Neuroene Therapeutics INC
- Study coordinator: Chan, Sherine S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.