A new treatment for pancreatic neuroendocrine tumors
Official title: A novel therapy for pancreatic neuroendocrine tumors
Funded at Wayne State University · NIH-10814877 · Data updated 2026-11-12
This study is exploring a new treatment for advanced pancreatic neuroendocrine tumors that aren't responding to current therapies, aiming to find better ways to help patients by understanding how cancer cells resist treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | April 1, 2020 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $336,000 |
| NIH project number | 5R01CA240607-05 |
| Project ID | NIH-10814877 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with advanced or metastatic pancreatic neuroendocrine tumors who have not responded to existing therapies.
✕Less likely to help
Patients with localized pancreatic neuroendocrine tumors who are eligible for surgical resection may not benefit from this research.
What this research studies
This research investigates a novel therapy aimed at treating pancreatic neuroendocrine tumors (PNETs), particularly in patients with advanced or metastatic disease where current treatments are ineffective. The approach focuses on understanding the mechanisms of drug resistance and targeting the NAD biosynthesis pathway, which is crucial for cancer cell metabolism. By studying patient-derived tissues and cell lines, the research aims to identify actionable therapeutic strategies that could improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could provide a new effective treatment option for patients with advanced pancreatic neuroendocrine tumors.
How similar studies have gone: Other research has shown promise in targeting metabolic pathways in cancer treatment, suggesting that this approach could be effective.
Where this research is happening
-
Wayne State University
Detroit, United States Active
Researchers
- Principal investigator: Azmi, Asfar S — Wayne State University
- Study coordinator: Azmi, Asfar S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.