A new treatment for drug-resistant bacteria using light and specific chemicals
A novel bacteria-specific pro-photosensitizer
['FUNDING_R21'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-11053606
This study is testing a new way to help people with stubborn infections in their wounds by using a special light and a plant-based treatment to target and kill tough bacteria that don't respond to regular antibiotics.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11053606 on ClinicalTrials.gov |
What this research studies
This research investigates a novel approach to combat multidrug-resistant bacteria, particularly those found in chronic wounds, by using a bacteria-specific pro-photosensitizer combined with blue light. The treatment aims to kill harmful bacteria like Acinetobacter baumannii and Pseudomonas aeruginosa, which are often resistant to traditional antibiotics. By utilizing a combination of light and specific phytochemicals, the researchers hope to develop a non-antibiotic therapy that can effectively reduce bacterial infections in patients. The study will also explore its effectiveness against other resistant bacteria that are common in hospital settings.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with chronic wounds infected by multidrug-resistant bacteria.
Not a fit: Patients with infections caused by bacteria that are not multidrug-resistant may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new, effective treatment option for patients suffering from infections caused by antibiotic-resistant bacteria.
How similar studies have performed: Other research has shown promising results using light-based therapies for bacterial infections, indicating potential success for this novel approach.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WU, MEI X — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: WU, MEI X
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.