A new tool to identify T cell targets in autoimmune neurological disorders
A synthetic biosensor of immunologic synapse formation allowing multiplexed T cell antigen discovery for autoimmune neurologic disorders
This study is working on a new tool that can quickly find important markers in the immune system, which could help doctors create better and safer treatments for people with autoimmune brain disorders like multiple sclerosis.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11078697 on NIH RePORTER |
What this research studies
This research focuses on developing a synthetic biosensor that can detect and evaluate multiple T cell antigens simultaneously, which are crucial in understanding autoimmune neurological disorders like multiple sclerosis and autoimmune encephalitis. By enhancing the ability to identify these antigens, the research aims to improve the precision of therapeutics, moving away from broad immunosuppressants to more targeted treatments. The project involves hands-on training in biosensor engineering and aims to collect data that will support future research applications. Patients may benefit from advancements in treatment options that are more effective and safer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autoimmune neurological disorders such as multiple sclerosis or autoimmune encephalitis.
Not a fit: Patients with non-autoimmune neurological conditions or those without a diagnosis of autoimmune disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer treatments for patients with autoimmune neurological disorders.
How similar studies have performed: Other research has shown success with high-throughput methods for antibody discovery, but this approach to T cell antigen discovery is relatively novel.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Gerdts, Josiah — University of California, San Francisco
- Study coordinator: Gerdts, Josiah
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.