A new therapy to reduce guilt in veterans with PTSD

Non-Inferiority Trial of Trauma Informed Guilt Reduction Therapy (TrIGR) for PTSD

['FUNDING_OTHER'] · VA SAN DIEGO HEALTHCARE SYSTEM · NIH-11077698

This study is testing a short therapy to help veterans with PTSD by focusing on feelings of guilt, making it easier for them to feel better and improve their overall mental health.

Quick facts

Phase['FUNDING_OTHER']
Study typeNih_funding
SexAll
SponsorVA SAN DIEGO HEALTHCARE SYSTEM (nih funded)
Locations1 site (SAN DIEGO, UNITED STATES)
Trial IDNIH-11077698 on ClinicalTrials.gov

What this research studies

This research investigates a brief therapy designed to help veterans with posttraumatic stress disorder (PTSD) by specifically targeting trauma-related guilt. The therapy aims to alleviate distressing emotions that often persist after traditional PTSD treatments, which can be lengthy and burdensome. By focusing on guilt reduction, the study seeks to improve overall mental health outcomes for veterans, potentially leading to better psychosocial functioning and reduced symptoms of depression and suicidal ideation. Participants will engage in a less intensive intervention that may be more accessible and effective for those struggling with PTSD.

Who could benefit from this research

Good fit: Ideal candidates for this research are veterans experiencing PTSD and trauma-related guilt.

Not a fit: Patients who do not have PTSD or trauma-related guilt may not receive benefit from this research.

Why it matters

Potential benefit: If successful, this research could provide veterans with a more effective and accessible treatment option for managing PTSD and associated guilt.

How similar studies have performed: Previous research has shown promise in using brief interventions for PTSD, indicating that this approach may be effective.

Where this research is happening

SAN DIEGO, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.