A new therapy to help children manage psychogenic non-epileptic seizures.

Retraining and Control Therapy (ReACT): Sense of control and catastrophic symptom expectations as targets of a cognitive behavioral treatment for pediatric psychogenic non-epileptic seizures (PNES)

NIH-funded research University of Alabama at Birmingham · NIH-10923998

This study is testing a new therapy called ReACT to help children who have non-epileptic seizures by teaching them how to better understand and manage their symptoms, so they can feel more in control and have fewer seizures.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionUniversity of Alabama at Birmingham NIH-funded
Lab location1 site (Birmingham, United States)
Project IDNIH-10923998 on NIH RePORTER

What this research studies

This research focuses on developing a cognitive behavioral treatment called Retraining and Control Therapy (ReACT) for children experiencing psychogenic non-epileptic seizures (PNES). The approach aims to address catastrophic symptom expectations and enhance the sense of control among young patients, which are believed to contribute to the severity of their symptoms. By utilizing techniques from cognitive behavioral therapy, the study seeks to empower children to manage their symptoms more effectively and reduce the frequency of seizures. The research builds on previous findings that suggest a strong link between a child's perception of their symptoms and their actual experience of PNES.

Who could benefit from this research

Good fit: Ideal candidates for this research are children aged 0-20 years who are diagnosed with psychogenic non-epileptic seizures.

Not a fit: Patients who do not have psychogenic non-epileptic seizures or those with other neurological disorders may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could significantly improve the quality of life for children with PNES by reducing seizure frequency and enhancing their sense of control over their condition.

How similar studies have performed: Previous studies have shown that cognitive behavioral approaches can be effective in managing symptoms in adults with PNES, suggesting potential for success in pediatric populations as well.

Where this research is happening

Birmingham, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.