A new test to quickly predict sepsis in patients
Official title: PredictSEP: A Predictive Diagnostic Assay for Sepsis
Funded at Cfd Research Corporation · NIH-10484762 · Data updated 2026-11-12
This study is working on a quick test that can help doctors predict how sepsis, a serious infection-related condition, might develop in patients by looking at certain white blood cells, so they can provide better care faster.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cfd Research Corporation NIH-funded |
| Lab location | 1 site (Huntsville, United States) |
| Project start | July 18, 2022 |
| Project end | December 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $342,689 |
| NIH project number | 1R43GM146559-01 |
| Project ID | NIH-10484762 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients diagnosed with sepsis, those with Systemic Inflammatory Response Syndrome (SIRS), and healthy individuals for comparison.
✕Less likely to help
Patients who are not experiencing symptoms of infection or those with chronic conditions unrelated to sepsis may not benefit from this research.
What this research studies
This research aims to develop a rapid diagnostic assay that can predict the onset and progression of sepsis, a life-threatening condition caused by the body's response to infection. By utilizing a microfluidics-based approach, the assay will analyze neutrophil behavior in patients to generate a predictive score that reflects their prognosis. The initial phase will validate the assay's effectiveness within 60 minutes using samples from sepsis patients, while the second phase will focus on creating the necessary instrumentation and conducting larger studies for FDA approval.
Why it matters
Potential benefit: If successful, this research could lead to faster and more accurate diagnosis of sepsis, potentially saving lives through timely treatment.
How similar studies have gone: Previous research has shown promise in developing rapid diagnostic assays for sepsis, but this specific approach utilizing neutrophil behavior is novel.
Where this research is happening
-
Cfd Research Corporation
Huntsville, United States Active
Researchers
- Principal investigator: Bhatt, Ketan H — Cfd Research Corporation
- Study coordinator: Bhatt, Ketan H
Related research
Other NIH-funded projects on the same topics.
-
Role of blood flow mechanics and transfusion in sepsis-related tiny-cl vessel clots
A patient-focused look at how red blood cell flow and transfusions might influence tiny blood vessel clots and organ problems in sepsis.
-
STeroids and enhanced Antibiotics for sepsis in Africa with HIV/TB (STARS)
This grant tests whether adding steroids and stronger antibiotics helps adults with severe sepsis tied to HIV/TB in areas with high TB rates.
-
Steroids and better antibiotics for sepsis in people with AIDS in Africa
This study tests whether adding hydrocortisone and stronger antibiotics can improve survival for adults with sepsis who also have AIDS or advanced immune suppression in regions with high TB.
-
Coordinating ARDS, Pneumonia, and Sepsis research to improve care
A national coordinating center helps researchers studying ARDS and related infections work together more efficiently to learn what helps patients recover.
-
Role of MMP3 in heart dysfunction during sepsis
This research tests whether blocking MMP3 can protect the heart and improve survival during sepsis in adults.
-
Sepsis patient care guided by Ugandan-wide immune profiling
A large NIH-funded study will map how the immune system behaves during sepsis in people in Uganda to improve personalized care for sepsis patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.