A new test for quickly identifying pathogens in endocarditis from blood samples
Official title: Commercialization Readiness Pilot (CRP) program support for: Direct-from-specimen identification of pathogens common in endocarditis
Funded at Helixbind, INC. · NIH-11094049 · Data updated 2026-11-12
This study is testing a new, quick test that can find germs causing infective endocarditis in your blood in just three hours, helping doctors give you the right treatment faster and more accurately than traditional methods.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Helixbind, INC. NIH-funded |
| Lab location | 1 site (Boxborough, UNITED STATES) |
| Project start | June 20, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $1,000,000 |
| NIH project number | 5SB1AI172440-03 |
| Project ID | NIH-11094049 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients suspected of having infective endocarditis, particularly those who may benefit from rapid diagnosis and targeted antimicrobial therapy.
✕Less likely to help
Patients who do not have infective endocarditis or those who are not experiencing symptoms related to this condition may not benefit from this research.
What this research studies
This research focuses on developing a rapid diagnostic test called RaPID/IE that can identify and characterize pathogens causing infective endocarditis directly from blood samples in about three hours. Unlike traditional methods that rely on blood cultures, which can take longer and may yield false negatives, this automated test provides faster and more accurate results. It is designed to detect both bacterial and fungal pathogens and includes a marker for antimicrobial resistance, ensuring that patients receive the most effective treatment promptly.
Why it matters
Potential benefit: If successful, this research could significantly reduce the time to diagnosis and improve treatment outcomes for patients with infective endocarditis.
How similar studies have gone: Other research has shown promise in developing rapid diagnostic tests for infectious diseases, indicating that this approach has potential for success.
Where this research is happening
-
Helixbind, INC.
Boxborough, United States Active
Researchers
- Principal investigator: Singer, Alon — Helixbind, INC.
- Study coordinator: Singer, Alon
Related research
Other NIH-funded projects on the same topics.
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Automated, culture-free test to detect bloodstream infections directly from blood
A new automated test called RaPID/BSI can identify bloodstream infections directly from a blood sample within four hours, helping doctors choose the right treatment sooner.
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Ultra-sensitive blood test to spot active Lyme disease infections
A new blood test called RaPID/LD aims to detect active Borrelia infections directly from blood, helping people with suspected Lyme disease get an early and accurate diagnosis.
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Automated test that quickly identifies bloodstream infections from a blood sample
A fast, blood-based test from HelixBind that can identify bloodstream infections within about 4 hours to guide the right treatment.
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Direct-from-specimen test for bloodstream infections
A fast, blood test developed by HelixBind to identify bloodstream infections directly from a blood sample in about 4 hours, helping doctors treat septicemia sooner.
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Direct-from-specimen test for fast endocarditis pathogens
A fast, automated blood test can identify bacteria or fungi causing endocarditis without culture, helping doctors choose the right treatment sooner.
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A faster way to detect bloodstream infections directly from blood
This project is creating a new device to quickly find out if you have a bloodstream infection, which can lead to a serious condition called sepsis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.