A new system for delivering cancer drugs directly to the brain
Smart CSF Delivery System for CNS Drug Therapy for Leptomeningeal Disease
['FUNDING_SBIR_1'] · ENCLEAR THERAPIES, INC. · NIH-10819360
This study is working on a new way to deliver chemotherapy directly into the fluid around the brain for patients with brain cancer, aiming to make the treatment more effective than the usual methods.
Quick facts
| Phase | ['FUNDING_SBIR_1'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ENCLEAR THERAPIES, INC. (nih funded) |
| Locations | 1 site (Newburyport, UNITED STATES) |
| Trial ID | NIH-10819360 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a smart delivery system that enhances the administration of chemotherapy drugs directly into the cerebrospinal fluid (CSF) for patients with brain cancer. By using a specialized platform, the study aims to improve the distribution and penetration of drugs like Topotecan, which are often ineffective when delivered through traditional intravenous methods due to the blood-brain barrier. The project will involve testing this delivery system in a large animal model to ensure its safety and effectiveness before considering human trials.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with leptomeningeal disease or brain tumors who require chemotherapy treatment.
Not a fit: Patients with conditions not involving the central nervous system or those who are not candidates for chemotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve treatment outcomes for patients with brain tumors by ensuring more effective drug delivery directly to affected areas.
How similar studies have performed: While the approach of enhancing drug delivery to the brain is being explored, this specific method of using a smart CSF delivery system is novel and has not been extensively tested in prior studies.
Where this research is happening
Newburyport, UNITED STATES
- ENCLEAR THERAPIES, INC. — Newburyport, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GLICKSMAN, MARCIE A — ENCLEAR THERAPIES, INC.
- Study coordinator: GLICKSMAN, MARCIE A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Animal Diseases