A new surgical technique to reduce side effects of prostate cancer surgery
Official title: Pelvic fascia spARing radical prostatectomy TrIAL (PARTIAL)
Funded at Weill Medical Coll of Cornell Univ · NIH-10925145 · Data updated 2026-11-12
This study is looking at a new type of prostate cancer surgery that aims to reduce long-term side effects like urinary incontinence and erectile dysfunction, and it's for men who are considering surgery for prostate cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | February 4, 2022 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $405,053 |
| NIH project number | 5R01CA259173-03 |
| Project ID | NIH-10925145 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are men diagnosed with localized prostate cancer who are considering radical prostatectomy as a treatment option.
✕Less likely to help
Patients with advanced prostate cancer or those who are not candidates for surgery may not benefit from this research.
What this research studies
This research investigates a novel surgical approach called pelvic fascia-sparing radical prostatectomy (PFS-RP) aimed at minimizing long-term side effects associated with traditional prostate cancer surgery. By preserving critical support structures and nerves during the procedure, the study seeks to reduce the incidence of urinary incontinence and erectile dysfunction, which are common complications of standard radical prostatectomy. The research will involve a multi-center, randomized controlled trial to gather robust data on the effectiveness of this technique compared to conventional methods. Patients will be monitored for various outcomes, including quality of life and oncologic endpoints, over an extended follow-up period.
Why it matters
Potential benefit: If successful, this research could significantly improve the quality of life for prostate cancer patients by reducing debilitating side effects associated with surgery.
How similar studies have gone: Previous smaller studies have shown promising results with the pelvic fascia-sparing technique, but this research aims to validate those findings in a larger, more rigorous trial.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Hu, Jim — Weill Medical Coll of Cornell Univ
- Study coordinator: Hu, Jim
Related research
Other NIH-funded projects on the same topics.
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New Diaphragm-like implant to prevent urinary leakage after prostate cancer surgery
A resorbable implant placed at the time of prostate cancer surgery helps men regain bladder control faster and reduces the need for pads or secondary procedures.
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Pelvic fascia-sparing radical prostatectomy: a better-path to fewer side effects
A large research project tests a new surgical approach for prostate cancer that may reduce urinary leakage and erectile problems after surgery.
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Preserving Erectile Function during Robotic Prostate Surgery by Measuring Nerve-Sparing Technique
Aims to create an objective way to measure how well surgeons perform the nerve-sparing part of robot-assisted prostate cancer surgery to help patients keep erectile function.
-
Tools that light up cancer and nerves during prostate removal
This project develops cameras and safe fluorescent dyes to show prostate cancer margins and nearby nerves in real time during prostate removal surgery for men with prostate cancer.
-
PSMA-PET imaging to guide prostate removal and protect nerves
This will see if a PSMA-PET scan using the 68Ga-P16-093 tracer can help surgeons choose nerve- and muscle-sparing surgery versus wider removal for men having prostatectomy for prostate cancer.
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Pelvic fascia-sparing prostate surgery
This research compares a pelvic fascia-sparing prostate removal to standard prostate surgery to try to lower long-term urinary and sexual side effects for men with localized prostate cancer.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.