A new stentgraft for delivering medicine to prevent blood vessel re-narrowing
A Retrievable, Chambered Stentgraft to Achieve Localized, High Intensity Drug Delivery for Treatment of Vascular Restenosis
This project is developing a new type of temporary stent to deliver medicine directly to blood vessels, helping people who experience re-narrowing after procedures like angioplasty.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11118692 on NIH RePORTER |
What this research studies
Many people who have procedures to open blocked blood vessels, like angioplasty, experience the vessel narrowing again, a problem called restenosis. Current treatments, such as drug-coated balloons, have limitations because much of the medicine can be lost in the bloodstream or cannot be delivered for long enough. This project is creating a special temporary stent, shaped like a dumbbell, that can deliver a high dose of medicine directly to the affected blood vessel. It works by isolating the treatment area while still allowing blood flow, then removing unused medicine before the stent is taken out. This approach aims to provide more effective treatment while reducing unwanted side effects throughout the body.
Who could benefit from this research
Good fit: Ideal candidates are individuals who have undergone angioplasty or similar procedures and are at risk for or have experienced vascular restenosis.
Not a fit: Patients who do not have vascular restenosis or are not candidates for stent-based interventions would not directly benefit from this specific device.
Why it matters
Potential benefit: If successful, this new device could significantly reduce the rate of blood vessel re-narrowing after procedures, potentially preventing the need for repeat interventions and reducing risks like heart attack or stroke.
How similar studies have performed: This approach introduces a novel design for localized drug delivery that aims to overcome limitations of existing drug-coated balloons, representing a new direction in preventing restenosis.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Tillman, Bryan W. — Ohio State University
- Study coordinator: Tillman, Bryan W.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.