A new sensor to study how cell structures form and dissolve
Official title: Quantitative Hydrophobicity Sensor to Probe the Dynamics of Biomolecular Condensates
Funded at Johns Hopkins University · NIH-10986259 · Data updated 2026-11-12
This study is looking at how tiny structures in our cells, called biomolecular condensates, form and break apart, using a special tool that lights up to help us see these changes in real-time, which could help us learn more about how our cells work and what happens when things go wrong.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $216,315 |
| NIH project number | 1R21DA061446-01 |
| Project ID | NIH-10986259 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to cellular dysfunction, such as cancer or neurodegenerative diseases.
✕Less likely to help
Patients with stable, non-progressive conditions that do not involve cellular dynamics may not benefit from this research.
What this research studies
This research focuses on understanding the dynamics of biomolecular condensates, which are essential for various cellular processes. By developing a genetically encoded hydrophobicity biosensor, the researchers aim to monitor how these condensates form and dissolve in real-time within living cells. The biosensor will utilize fluorescent proteins to provide insights into the hydrophobic interactions that influence the stability of these cellular structures. This innovative approach could enhance our understanding of cellular functions and their implications in health and disease.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding cellular processes that are crucial for various diseases, including cancer.
How similar studies have gone: Other research has shown promise in using biosensors for monitoring cellular processes, indicating that this approach could be effective.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Chen, Yun — Johns Hopkins University
- Study coordinator: Chen, Yun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.