A new sensor to study how cell structures form and dissolve
Quantitative Hydrophobicity Sensor to Probe the Dynamics of Biomolecular Condensates
['FUNDING_R21'] · JOHNS HOPKINS UNIVERSITY · NIH-10986259
This study is looking at how tiny structures in our cells, called biomolecular condensates, form and break apart, using a special tool that lights up to help us see these changes in real-time, which could help us learn more about how our cells work and what happens when things go wrong.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10986259 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the dynamics of biomolecular condensates, which are essential for various cellular processes. By developing a genetically encoded hydrophobicity biosensor, the researchers aim to monitor how these condensates form and dissolve in real-time within living cells. The biosensor will utilize fluorescent proteins to provide insights into the hydrophobic interactions that influence the stability of these cellular structures. This innovative approach could enhance our understanding of cellular functions and their implications in health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to cellular dysfunction, such as cancer or neurodegenerative diseases.
Not a fit: Patients with stable, non-progressive conditions that do not involve cellular dynamics may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding cellular processes that are crucial for various diseases, including cancer.
How similar studies have performed: Other research has shown promise in using biosensors for monitoring cellular processes, indicating that this approach could be effective.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEN, YUN — JOHNS HOPKINS UNIVERSITY
- Study coordinator: CHEN, YUN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.