A new rotavirus vaccine using a safe probiotic
Novel recombinant Rotavirus vaccine utilizing the probiotic microorganism Lactobacillus acidophilus
This study is testing a new rotavirus vaccine made from a friendly probiotic called Lactobacillus acidophilus, designed to give better protection to young children under five in developing countries, and it will be easy to take and store without needing refrigeration.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Colorado State University NIH-funded |
| Lab location | 1 site (Fort Collins, United States) |
| Project ID | NIH-10747295 on NIH RePORTER |
What this research studies
This research focuses on developing a novel rotavirus vaccine that utilizes the probiotic microorganism Lactobacillus acidophilus. The vaccine aims to provide better protection against rotavirus, particularly for children under five years old in developing countries, where existing vaccines have lower efficacy. The approach involves creating an orally-delivered vaccine that is safe, cost-effective, and does not require cold storage. The researchers will use advanced techniques, including CRISPR-Cas9, to enhance the vaccine's effectiveness and assess its ability to induce strong immune responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under the age of five, especially those living in developing countries where rotavirus is a major health concern.
Not a fit: Patients who are older than five years or those living in developed countries may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the incidence of severe rotavirus disease and related deaths in young children, particularly in developing nations.
How similar studies have performed: Other research has shown promise in developing vaccines using probiotics, but this specific approach utilizing Lactobacillus acidophilus is relatively novel.
Where this research is happening
Fort Collins, United States
- Colorado State University — Fort Collins, United States (Active)
Researchers
- Principal investigator: Dean, Gregg a — Colorado State University
- Study coordinator: Dean, Gregg a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.