NIH-funded research NIH-funded research

A new probiotic to help manage obesity and insulin resistance

Official title: A Novel Probiotic with The Potential for Long-term Management of Obesity and Insulin Resistance

Funded at Epic Nutrition for Y LLC · NIH-10919649 · Data updated 2026-11-12

This study is looking at a new probiotic called Clostridium cochlearium 2316 to see if it can help people manage obesity and insulin resistance by improving gut health through diet, offering a friendly and affordable way to support weight loss and better blood sugar control.

More Obesity research and trials

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionEpic Nutrition for Y LLC
NIH-funded
Lab location1 site (Troy, United States)
Project startSeptember 15, 2024
Project endJuly 31, 2026
Funding year2024
Award (this year)$194,275
NIH project number1R41DK139815-01
Project IDNIH-10919649 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are individuals struggling with obesity and insulin resistance, particularly those who have not found success with current treatment options.

Less likely to help

Patients who are not overweight or do not have insulin resistance may not benefit from this research.

What this research studies

This research investigates a novel probiotic strain, Clostridium cochlearium 2316, which may offer a long-term solution for managing obesity and insulin resistance. The approach focuses on dietary supplementation with this safe bacterium, which has shown promising results in preliminary studies by significantly reducing body weight gain and improving insulin sensitivity in animal models. The goal is to develop a non-invasive and cost-effective nutritional intervention that can alter the gut microbiome positively. Patients may benefit from a new dietary strategy that could complement existing obesity treatments.

Why it matters

Potential benefit: If successful, this research could provide a sustainable and effective method for managing obesity and insulin resistance in patients.

How similar studies have gone: Preliminary studies have shown success with similar probiotic approaches, indicating potential for this novel intervention.

Where this research is happening

  • Epic Nutrition for Y LLC
    Troy, United States
    Active

Researchers

  • Principal investigator: Zhou, Kequan — Epic Nutrition for Y LLC
  • Study coordinator: Zhou, Kequan

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.