A new plug to help heal perianal fistulas
A nanofiber-hydrogel composite plug for perianal fistula repair
['FUNDING_R01'] · JOHNS HOPKINS UNIVERSITY · NIH-11035156
This study is testing a new type of plug made from special materials to help heal perianal fistulas in people with Crohn's disease by using stem cells to boost the body's natural healing, and it's being tried out in animals first to see how well it works and if it's safe.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11035156 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a specialized plug made from a nanofiber-hydrogel composite designed to repair perianal fistulas, which are common complications in patients with Crohn's disease. The approach involves creating a biostimulatory device that promotes tissue healing by delivering adipose-derived stem cells and enhancing the body's natural healing processes. The researchers will test this plug in animal models that closely mimic the condition in humans to evaluate its effectiveness and safety.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with perianal fistulas, particularly those related to Crohn's disease.
Not a fit: Patients with perianal fistulas not related to Crohn's disease or those who have already undergone multiple unsuccessful treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve healing rates for patients suffering from perianal fistulas, leading to better quality of life.
How similar studies have performed: Previous studies have shown promise in using similar biocompatible materials for tissue repair, indicating potential for success in this novel approach.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MAO, HAI-QUAN — JOHNS HOPKINS UNIVERSITY
- Study coordinator: MAO, HAI-QUAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.