A new platform to study microRNA changes in cancer
Official title: isomiRGate: a comprehensive gateway for studying the canonical and modified microRNAomes in Cancer
Funded at Ohio State University · NIH-10989238 · Data updated 2026-11-12
This study is looking at how changes in tiny molecules called microRNAs, which help control genes, can affect cancer, with the goal of finding new ways to diagnose and monitor the disease, so patients can get better care.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | June 1, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $390,290 |
| NIH project number | 1R21CA287180-01A1 |
| Project ID | NIH-10989238 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are diagnosed with cancer or at risk of developing cancer.
✕Less likely to help
Patients with non-cancerous conditions or those under 21 years old may not receive any benefit from this research.
What this research studies
This research focuses on understanding how modifications to microRNAs (small RNA molecules that regulate gene expression) can impact cancer biology. By profiling both canonical and modified microRNAs, the project aims to identify new biomarkers that could help in the diagnosis and monitoring of cancer. The approach involves advanced techniques in epitranscriptomics, which examines RNA modifications that may alter the function of these microRNAs. Patients may benefit from the insights gained, as they could lead to improved detection and treatment strategies for various cancers.
Why it matters
Potential benefit: If successful, this research could lead to the discovery of novel biomarkers for cancer diagnosis and treatment.
How similar studies have gone: Previous research has shown promise in using modified microRNAs as biomarkers in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Nigita, Giovanni — Ohio State University
- Study coordinator: Nigita, Giovanni
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.