A new platform for rapidly evolving enzymes and biocatalysts
Official title: A universal droplet microfluidic platform for ultrahigh-throughput biocatalyst evolution
Funded at Fluid Discovery INC · NIH-10705725 · Data updated 2026-11-12
This study is working on a new technology that helps scientists quickly find and improve special proteins called enzymes, which could lead to better treatments for patients in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fluid Discovery INC NIH-funded |
| Lab location | 1 site (San Francisco, UNITED STATES) |
| Project start | September 25, 2021 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $817,050 |
| NIH project number | 5R42GM143989-03 |
| Project ID | NIH-10705725 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals with conditions that could be treated or improved by advanced biocatalysts, such as metabolic disorders or those requiring enzyme replacement therapies.
✕Less likely to help
Patients with conditions unrelated to enzyme function or those not requiring biotechnological interventions may not receive any benefit from this research.
What this research studies
This research focuses on developing a cutting-edge microfluidic platform that allows for the rapid screening and evolution of genetically engineered enzymes. By utilizing precision nanoliter fluid handling and advanced mass spectrometry techniques, the project aims to significantly increase the efficiency and scale of enzyme screening, making it 100 times more effective than current methods. Patients may benefit indirectly through advancements in biotechnology that could lead to improved therapies and treatments derived from enhanced enzymes. The project is designed to create an alpha prototype that can be tested by early access customers, showcasing its potential for industrial applications.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective biocatalysts, which may improve various medical treatments and biotechnological applications.
How similar studies have gone: Other research in enzyme evolution and biocatalyst development has shown promise, indicating that this approach could lead to significant advancements in the field.
Where this research is happening
-
Fluid Discovery INC
San Francisco, United States Active
Researchers
- Principal investigator: Prince, Robin — Fluid Discovery INC
- Study coordinator: Prince, Robin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.