A new nose spray vaccine for the flu
IND-enabling studies of an intranasal, single-replication M2SR influenza vaccine
This research is developing a new type of flu vaccine, given as a nose spray, to offer better protection against different flu strains for adults.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Flugen, INC. NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11136494 on NIH RePORTER |
What this research studies
Current flu vaccines don't always protect well, especially when the flu virus changes. This project is working on a new kind of flu vaccine, called M2SR, that is given as a nose spray. It's designed to provide stronger protection against various flu strains, including those that have changed or are very dangerous. The goal is to prepare this vaccine for future testing in people, building on promising results seen in animal models and early human safety tests.
Who could benefit from this research
Good fit: Ideal candidates for future studies might include healthy adults, particularly those aged 21 and older, including seniors.
Not a fit: Patients who are not eligible for vaccination or who have specific contraindications to nasal vaccines may not receive benefit.
Why it matters
Potential benefit: If successful, this vaccine could offer more reliable and broader protection against the flu, potentially reducing hospitalizations and deaths.
How similar studies have performed: A prototype of this M2SR vaccine has shown promising safety and immune responses in early clinical trials and provided protection in animal models against various flu strains.
Where this research is happening
Madison, United States
- Flugen, INC. — Madison, United States (Active)
Researchers
- Principal investigator: Bilsel, Pamuk — Flugen, INC.
- Study coordinator: Bilsel, Pamuk
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.