A new non-hormonal contraceptive intravaginal ring using anti-sperm antibodies

Nonhormonal contraceptive intravaginal ring based on high valency anti-sperm antibody constructs

['FUNDING_OTHER'] · MUCOMMUNE, LLC · NIH-10693139

This study is testing a new type of birth control that uses a special ring you can place inside your body to release antibodies that catch sperm, giving women a non-hormonal option that’s easy to use without needing to take something every day or worry about timing.

Quick facts

Phase['FUNDING_OTHER']
Study typeNih_funding
SexAll
SponsorMUCOMMUNE, LLC (nih funded)
Locations1 site (Morrisville, UNITED STATES)
Trial IDNIH-10693139 on ClinicalTrials.gov

What this research studies

This research aims to develop a non-hormonal contraceptive method using an intravaginal ring that releases antibodies to bind and trap sperm, preventing fertilization. The approach focuses on creating a user-controlled device that does not require daily dosing or coital timing, addressing common concerns about hormonal contraceptives. By utilizing advances in antibody production, the study seeks to provide a practical and effective alternative for women who prefer non-hormonal options. The research builds on previous animal model validations to ensure safety and efficacy in humans.

Who could benefit from this research

Good fit: Ideal candidates for this research are women of reproductive age who are seeking non-hormonal contraceptive methods.

Not a fit: Patients who are not seeking contraceptive options or those who prefer hormonal methods may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could provide women with a safe, effective, and user-friendly contraceptive option that does not involve hormones.

How similar studies have performed: Previous research has shown promise in using antibody-based methods for contraception, but this specific approach with an intravaginal ring is novel.

Where this research is happening

Morrisville, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.