A New MRI Scan for Heart Blood Flow Problems
Noninvasive Testing of Coronary Microvascular Reactivity Using High-resolution Free-breathing MRI
['FUNDING_R01'] · PURDUE UNIVERSITY · NIH-11284315
This project is developing a new, gentle MRI scan to find out why some people have chest pain even when their main heart arteries are clear.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PURDUE UNIVERSITY (nih funded) |
| Locations | 1 site (WEST LAFAYETTE, UNITED STATES) |
| Trial ID | NIH-11284315 on ClinicalTrials.gov |
What this research studies
Many people experience chest pain, or angina, but traditional tests show their major heart arteries are not blocked. This condition is called INOCA, and it's often caused by problems with the tiny blood vessels in the heart, known as coronary microvascular dysfunction (CMD). Currently, finding CMD requires an invasive procedure with some risks. This research aims to create a special MRI scan that can safely and easily check these small heart vessels, helping doctors understand and treat CMD better.
Who could benefit from this research
Good fit: Ideal candidates are patients experiencing chest pain or angina who have been told their main heart arteries are not blocked.
Not a fit: Patients with clear blockages in their main heart arteries or those without heart-related symptoms may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this new MRI scan could offer a safer, non-invasive way to diagnose heart blood flow problems for patients with chest pain, avoiding risky procedures.
How similar studies have performed: Previous imaging methods have shown only weak connections to the invasive test, suggesting this new high-resolution MRI approach is a novel and potentially more accurate method.
Where this research is happening
WEST LAFAYETTE, UNITED STATES
- PURDUE UNIVERSITY — WEST LAFAYETTE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHARIF, BEHZAD — PURDUE UNIVERSITY
- Study coordinator: SHARIF, BEHZAD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.