A new mouse model to investigate treatments for chronic Hepatitis B virus infection
Official title: A new humanized mouse model to study HBV gene editing
Funded at Fred Hutchinson Cancer Center · NIH-10981535 · Data updated 2026-11-12
This study is creating a special type of mouse that acts like a human liver to test new gene editing treatments for chronic Hepatitis B, helping researchers find better ways to clear the virus from the body.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $862,440 |
| NIH project number | 1R01AI175949-01A1 |
| Project ID | NIH-10981535 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic Hepatitis B virus infection who have not responded to existing therapies.
✕Less likely to help
Patients with acute Hepatitis B infection or those who have already achieved viral clearance may not benefit from this research.
What this research studies
This research focuses on developing a humanized mouse model to study chronic Hepatitis B virus (HBV) infection, which affects millions globally. The team aims to evaluate novel gene editing therapies that target HBV by using a specially designed mouse that mimics human liver conditions. By employing advanced techniques like AAV vectors and lipid nanoparticles, the researchers will assess the effectiveness of these therapies in clearing the virus from infected cells. This approach aims to overcome the limitations of existing animal models and provide a more accurate platform for testing potential treatments.
Why it matters
Potential benefit: If successful, this research could lead to new, effective treatments for chronic Hepatitis B virus infection, potentially curing the disease for many patients.
How similar studies have gone: Previous research has shown promise in using gene editing techniques for viral infections, indicating potential success for this novel approach.
Where this research is happening
-
Fred Hutchinson Cancer Center
Seattle, United States Active
Researchers
- Principal investigator: Jerome, Keith R — Fred Hutchinson Cancer Center
- Study coordinator: Jerome, Keith R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.