A new mouse model to improve genome editing detection
Official title: A Novel Mouse Model for the Detection of Genome Editing
Funded at Baylor College of Medicine · NIH-11137479 · Data updated 2026-11-12
This study is creating a new mouse model to help scientists better see and confirm when gene editing works using CRISPR technology, which could lead to safer and more effective treatments for people needing gene therapy.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | May 1, 2025 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $240,039 |
| NIH project number | 1R21OD037647-01A1 |
| Project ID | NIH-11137479 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research would be individuals with genetic conditions that could be treated through advanced genome editing techniques.
✕Less likely to help
Patients with conditions that are not amenable to genome editing or those who do not have genetic disorders may not receive benefit from this research.
What this research studies
This research focuses on developing a novel mouse model that enhances the detection of genome editing events using CRISPR/Cas9 technology. By utilizing advanced delivery methods for the editing components, the study aims to improve the efficiency of genome editing in targeted tissues while minimizing unintended effects in non-target tissues. The model will employ bioluminescent markers to visualize and confirm successful editing events, providing researchers with valuable tools for pre-clinical testing. This approach could lead to safer and more effective genome editing therapies.
Why it matters
Potential benefit: If successful, this research could lead to more precise and safer genome editing therapies for patients with genetic disorders.
How similar studies have gone: Other research has shown success with similar genome editing models, indicating a promising avenue for further exploration.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Walkey, Christopher John — Baylor College of Medicine
- Study coordinator: Walkey, Christopher John
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.