A new model to test how radiation and drugs affect tissues
Official title: PHASE I AWARD - AN ORGAN-ON-VASCULARNET MODEL FOR IN VITRO EVALUATION OF RADIATION AND DRUG THERAPIES
Funded at Chromologic, LLC · NIH-11191354 · Data updated 2026-11-12
This study is creating a special 3D model that acts like human tissue and blood vessels to see how they react to radiation and medicine, helping researchers find better ways to treat cancer without using animals for testing.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Chromologic, LLC NIH-funded |
| Lab location | 1 site (Monrovia, United States) |
| Project start | September 16, 2024 |
| Project end | September 15, 2025 |
| Funding year | 2024 |
| Award (this year) | $399,975 |
| NIH project number | 75N91024C00068-0-9999-1 |
| Project ID | NIH-11191354 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that require innovative drug therapies, particularly those involving immune checkpoint inhibitors and radiation treatment.
✕Less likely to help
Patients who are not undergoing treatment involving radiation or immune checkpoint inhibitors may not benefit from this research.
What this research studies
This research develops a 3D organ-on-chip model called Organ-on-VascularNet, which mimics human tissue and blood vessel interactions to evaluate the effects of radiation and drug therapies. By exposing this model to x-ray irradiation and interferon treatment, researchers aim to observe how normal and cancerous tissues respond, providing insights that could replace animal testing. The goal is to create a more accurate representation of human responses to treatments, which could lead to better drug development and therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer drug therapies for patients by improving the drug development process.
How similar studies have gone: Other research has shown promise with organ-on-chip models in drug testing, indicating that this approach could be a significant advancement in the field.
Where this research is happening
-
Chromologic, LLC
Monrovia, United States Active
Researchers
- Principal investigator: Rogers, Claude — Chromologic, LLC
- Study coordinator: Rogers, Claude
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.