A new model to study the spread of deadly colorectal and gastric cancers.
A vascularized microphysiological system (MPS) platform for modeling peritoneal carcinomatosis
This study is creating a special lab model to learn more about how cancer spreads in the abdomen, which could help improve treatments for patients with colorectal and gastric cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11094078 on NIH RePORTER |
What this research studies
This research focuses on developing a sophisticated laboratory model to better understand peritoneal carcinomatosis, a severe form of cancer spread from colorectal and gastric tumors. By utilizing a vascularized microphysiological system, researchers will observe how cancer cells behave in a 3D environment that mimics the human body. This approach aims to fill the gaps in current knowledge about cancer metastasis and improve the development of effective therapies. Patients may benefit from advancements in treatment options that arise from this innovative model.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with colorectal or gastric cancer, particularly those experiencing peritoneal carcinomatosis.
Not a fit: Patients with early-stage colorectal or gastric cancer without metastasis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for patients suffering from peritoneal carcinomatosis.
How similar studies have performed: Previous research using similar microphysiological systems has shown promise in understanding cancer biology and developing new treatments.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Hughes, Christopher C. W. — University of California-Irvine
- Study coordinator: Hughes, Christopher C. W.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.