A new model to study the spread of deadly colorectal and gastric cancers.

Who could benefit from this research

What this research studies

This research focuses on developing a sophisticated laboratory model to better understand peritoneal carcinomatosis, a severe form of cancer spread from colorectal and gastric tumors. By utilizing a vascularized microphysiological system, researchers will observe how cancer cells behave in a 3D environment that mimics the human body. This approach aims to fill the gaps in current knowledge about cancer metastasis and improve the development of effective therapies. Patients may benefit from advancements in treatment options that arise from this innovative model.

Why it matters

Where this research is happening

• University of California-Irvine
  Irvine, United States Active

Researchers

• Principal investigator: Hughes, Christopher C. W. — University of California-Irvine
• Study coordinator: Hughes, Christopher C. W.

Related research

Other NIH-funded projects on the same topics.

• Repeated PIPAC plus standard platinum–taxane chemotherapy for advanced ovarian cancer with peritoneal spread

  This test sees if adding repeated cisplatin-based PIPAC to standard platinum–taxane chemotherapy helps women aged 18–75 with newly diagnosed FIGO IIIB–IIIC epithelial ovarian cancer and visible peritoneal carcinomatosis.

  Recruiting Phase 2 Moscow Regional Oncological Dispensary · Balashikha · NCT07514494

• Enhanced Recovery After Surgery for adults with peritoneal carcinomatosis undergoing cytoreductive surgery with or without HIPEC

  This project will try an Enhanced Recovery After Surgery (ERAS) program to see if it shortens hospital stays after cytoreductive surgery with or without HIPEC for adults with peritoneal carcinomatosis.

  Recruiting Fondazione del Piemonte per l'Oncologia · Candiolo, Turin and 1 other locations · NCT07493876

• PIPAC with Mitomycin C for unresectable peritoneal cancer

  This phase 1 study tests a breathy, pressurized chemotherapy method (PIPAC-MMC) to see if it is safe and tolerable for adults with unresectable peritoneal carcinomatosis from colorectal, appendiceal, or small bowel cancers.

  Recruiting Phase 1 H. Lee Moffitt Cancer Center and Research Institute · Tampa, Florida · NCT07487168

• Heated versus aerosolized chemotherapy delivered into the abdomen for cancer that has spread to the peritoneum

  This study will test whether heated (HIPEC) or aerosolized (PIPAC) mitomycin-based chemotherapy given into the abdomen works better and is safer for adults whose cancer has spread to the peritoneum.

  Recruiting Phase 2 Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) · Pittsburgh, Pennsylvania · NCT07282834

• Adding paclitaxel into the abdominal cavity for gastric cancer that has spread to the peritoneum

  This trial will try adding paclitaxel delivered directly into the abdomen to standard IV chemotherapy for people with gastric or gastroesophageal junction cancer that has spread to the lining of the abdominal cavity to see if it slows disease growth and helps them live longer.

  Recruiting at 78 sites Phase 2/3 Eastern Cooperative Oncology Group · Irvine, California and 77 other locations · NCT07001748

• Blood clearance of nucleosomes and CTCF after surgery for colorectal cancer with peritoneal spread

  This test will see if blood levels of nucleosomes and CTCF can indicate whether adults with colorectal cancer that has spread to the peritoneum have had all visible tumor removed by cytoreductive surgery.

  Recruiting Hospices Civils de Lyon · Pierre-Bénite · NCT06929013

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.