A new microscopy system to study complex cell signaling pathways.
High-content microscopy platform for multiplex perturbation/multiplex readout studies
This study is looking at how changes in genes affect how cells communicate with each other, using special imaging techniques to see these interactions in real-time, which could help us understand more about how our cells work.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11098303 on NIH RePORTER |
What this research studies
This research focuses on using advanced microscopy techniques to explore how genetic changes affect cell signaling in mammalian cells. By employing a next-generation CRISPR system, researchers will create multiple genetic modifications and analyze the resulting cellular responses using high-throughput imaging. This approach allows for the simultaneous examination of various signaling pathways and their interactions, providing insights into cellular behavior and communication.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions influenced by cellular signaling pathways, such as cancer or genetic disorders.
Not a fit: Patients with conditions unrelated to cellular signaling or those not eligible for genetic perturbation studies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of cell signaling mechanisms, potentially informing new therapeutic strategies for diseases related to these pathways.
How similar studies have performed: Previous research using high-content microscopy and CRISPR technology has shown promising results in understanding complex biological systems, indicating that this approach has potential for success.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Hart, Glen Traver — University of Tx Md Anderson Can Ctr
- Study coordinator: Hart, Glen Traver
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.