A new microscope for advanced bioimaging techniques
Metasurface-Integrated Open-Top Lattice Light Sheet Microscope for High-Throughput Bioimaging
['FUNDING_R21'] · PRINCETON UNIVERSITY · NIH-11053628
This study is working on a new type of microscope that helps scientists see and follow how cells and groups of cells interact in real-time, which could lead to better insights into how our bodies work.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PRINCETON UNIVERSITY (nih funded) |
| Locations | 1 site (Princeton, UNITED STATES) |
| Trial ID | NIH-11053628 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a novel lattice light sheet microscope that enhances the ability to visualize and track dynamic interactions within cells and multicellular organisms in four dimensions. By improving the compatibility of this advanced imaging technology with commonly used sample holders, the project aims to overcome current limitations in biomedical research. The approach utilizes adaptive optics to correct optical aberrations, ensuring high-resolution imaging with minimal invasiveness. This could significantly improve the understanding of biological processes at the cellular level.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve complex cellular interactions, such as cancer or genetic disorders.
Not a fit: Patients with conditions that do not involve cellular imaging or those who are not undergoing treatment that requires advanced bioimaging may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in how we visualize and understand complex biological interactions, potentially improving diagnostics and treatment strategies.
How similar studies have performed: While light sheet fluorescence microscopy has shown promise in previous studies, this specific approach to integrating it with common sample holders is novel and has not been extensively tested.
Where this research is happening
Princeton, UNITED STATES
- PRINCETON UNIVERSITY — Princeton, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FU, TIAN-MING — PRINCETON UNIVERSITY
- Study coordinator: FU, TIAN-MING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.