A new microscope for advanced 3D imaging in biomedical research
Official title: Omni Oblique Plane Microscope to spread light-sheet based imaging in biomedical research
Funded at Ut Southwestern Medical Center · NIH-11017838 · Data updated 2026-11-12
This study is working on a new imaging tool that helps scientists take clearer 3D pictures of living cells and organs, especially to better understand heart cells and test new heart treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $316,755 |
| NIH project number | 5R01EB035538-02 |
| Project ID | NIH-11017838 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cardiac conditions who may benefit from new therapies being evaluated at the cellular level.
✕Less likely to help
Patients with non-cardiac conditions or those not requiring advanced imaging techniques may not receive direct benefits from this research.
What this research studies
This research focuses on developing a universal light-sheet fluorescence microscopy (LSFM) platform that enhances 3D imaging capabilities for various biological applications. By improving the adaptability of LSFM, the project aims to facilitate sensitive live cell imaging and the examination of transparent organs and tissues. The platform will also allow for high-resolution imaging of human heart cells, enabling researchers to evaluate new cardiac therapies at a molecular level. The study will utilize advanced statistical methods to analyze calcium signaling patterns in both healthy and diseased states.
Why it matters
Potential benefit: If successful, this research could significantly enhance the understanding and treatment of cardiac conditions by providing detailed insights into cellular processes.
How similar studies have gone: Previous research has demonstrated the effectiveness of light-sheet microscopy in various biological applications, indicating a promising potential for this novel approach.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Fiolka, Reto Paul — Ut Southwestern Medical Center
- Study coordinator: Fiolka, Reto Paul
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.