A new method to quickly identify bloodstream infections.
Official title: Highly Multiplexed Single Molecule Tethering
Funded at Scanogen, INC. · NIH-10909305 · Data updated 2026-11-12
This study is testing a new, quick way to find germs in the blood of patients with sepsis, so doctors can start the right treatment faster and help more people get better.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scanogen, INC. NIH-funded |
| Lab location | 1 site (Baltimore, UNITED STATES) |
| Project start | August 17, 2023 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $999,900 |
| NIH project number | 5R44AI179310-02 |
| Project ID | NIH-10909305 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients exhibiting symptoms of sepsis or suspected bloodstream infections.
✕Less likely to help
Patients with infections not caused by the targeted organisms or those who do not exhibit sepsis symptoms may not benefit from this research.
What this research studies
This research focuses on developing a rapid and comprehensive molecular assay that can identify pathogens directly from whole blood samples in patients showing symptoms of sepsis. The innovative approach, known as Single Molecule Tethering (SMOLT), allows for the detection of multiple microbes simultaneously, significantly reducing the time it takes to diagnose bloodstream infections. The assay is designed to work with low concentrations of microbes and aims to cover over 99% of the organisms responsible for these infections. By integrating this assay into an automated system, the goal is to provide timely and effective antimicrobial therapy to patients.
Why it matters
Potential benefit: If successful, this research could lead to faster diagnosis and treatment of bloodstream infections, potentially saving lives.
How similar studies have gone: Previous research has shown promise in rapid pathogen detection methods, but this approach aims to significantly enhance multiplexing capabilities, making it a novel advancement.
Where this research is happening
-
Scanogen, INC.
Baltimore, United States Active
Researchers
- Principal investigator: Celedon, Alfredo Andres — Scanogen, INC.
- Study coordinator: Celedon, Alfredo Andres
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.