A new method to measure cancer and healthy tissue contributions in blood
Official title: A SYNTHETIC BIOMARKER TO UNIVERSALLY ASSESS THE RELATIVE CONTRIBUTION OF HEATHY AND CANCEROUS TISSUE TO CIRCULATING EV POOL
Funded at Ohio State University · NIH-10993104 · Data updated 2026-11-12
This study is looking to create a new, easy way to check for cancer by examining tiny particles in the blood that come from both healthy and cancerous tissues, which could help doctors catch cancer earlier and track how it's changing over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | December 15, 2022 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $455,331 |
| NIH project number | 5R01CA270251-03 |
| Project ID | NIH-10993104 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for cancer or those undergoing treatment for cancer.
✕Less likely to help
Patients with non-cancerous conditions or those who are not at risk for cancer may not benefit from this research.
What this research studies
This research focuses on developing a synthetic biomarker that can assess the contributions of healthy and cancerous tissues to circulating extracellular vesicles (EVs) in the bloodstream. By analyzing these EVs, which are released by cells, the research aims to create a non-invasive tool for early cancer diagnosis and monitoring disease progression. The approach involves comparing the EVs from healthy animals to those from animals with cancer to better understand the differences and improve cancer detection methods. This could lead to more accurate and reliable cancer diagnostics.
Why it matters
Potential benefit: If successful, this research could provide a groundbreaking tool for early cancer detection and monitoring, improving patient outcomes.
How similar studies have gone: Previous research has shown promise in using extracellular vesicles for cancer diagnostics, but this approach aims to address existing limitations, making it a novel effort.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Cocucci, Emanuele — Ohio State University
- Study coordinator: Cocucci, Emanuele
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.