A new method to measure brain aging using epigenetic markers
A Novel Epigenetic Clock for Brain Aging
['FUNDING_R01'] · RUSH UNIVERSITY MEDICAL CENTER · NIH-11142977
This study is looking to create a new tool that helps measure how our brains age, especially for people 65 and older, by checking certain changes in DNA that could help us understand and tackle issues like Alzheimer's.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUSH UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11142977 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a novel epigenetic clock that measures biological aging in the brain, particularly for individuals aged 65 and older. By analyzing DNA methylation levels at specific sites, the study aims to create a biomarker that can accurately reflect brain aging and its association with neurodegenerative diseases like Alzheimer's. The approach involves using ribosomal DNA methylation, which has shown strong correlations with age, to construct a reliable clock that can help in understanding and potentially mitigating age-related cognitive decline. Patients may be involved in providing biological samples to validate the effectiveness of this new clock.
Who could benefit from this research
Good fit: Ideal candidates for participation are individuals aged 65 and older, particularly those concerned about cognitive health or at risk for neurodegenerative diseases.
Not a fit: Patients younger than 65 or those without any cognitive health concerns may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools for assessing brain health and aging, ultimately improving treatment strategies for neurodegenerative diseases.
How similar studies have performed: While there have been successful studies using epigenetic clocks in younger populations, this specific approach targeting brain aging in older adults is novel and has not been extensively tested.
Where this research is happening
CHICAGO, UNITED STATES
- RUSH UNIVERSITY MEDICAL CENTER — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GRODSTEIN, FRANCINE — RUSH UNIVERSITY MEDICAL CENTER
- Study coordinator: GRODSTEIN, FRANCINE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.