A new method to improve islet transplantation for diabetes treatment
A stem cell activated cryogel bioscaffold that restores islet bioenergetics while providing oxygen and nutrients at extravascular sites of transplantation
This study is looking at a new way to help people with diabetes who need islet transplants by creating a special 3D support that gives the islets the oxygen and nutrients they need to survive better after the procedure, which could lead to improved diabetes management for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11059874 on NIH RePORTER |
What this research studies
This research focuses on enhancing islet transplantation, a therapy for diabetic patients who cannot produce insulin. The team is developing a specialized 3D bioscaffold that provides essential oxygen and nutrients to islets during and after transplantation, addressing the challenges of islet survival in the liver. By using a collagen-based cryogel matrix with an oxygen generator, the research aims to improve islet health and reduce the loss of islets that typically occurs after transplantation. Patients may benefit from a more effective treatment option that could lead to better management of their diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research are diabetic patients who are considering or are eligible for islet transplantation.
Not a fit: Patients who do not have diabetes or are not candidates for islet transplantation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved outcomes for diabetic patients undergoing islet transplantation.
How similar studies have performed: Other research has shown promise in using bioscaffolds for cell transplantation, indicating potential success for this innovative approach.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Thakor, Avnesh Sinh — Stanford University
- Study coordinator: Thakor, Avnesh Sinh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.