A new method to control pain after oral surgery without opioids
Official title: A Novel Opioid-Free Targeted Pain Control Method for Acute Post-Operative Localized Pain Related to Oral Surgical Procedures
Funded at Revbio, INC. · NIH-10761260 · Data updated 2026-11-12
This study is testing a new way to help manage pain after dental surgeries, like getting your wisdom teeth out, using a special adhesive that delivers medicine right where it hurts, so you won't need opioids and can feel better safely.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Revbio, INC. NIH-funded |
| Lab location | 1 site (Lowell, UNITED STATES) |
| Project start | September 19, 2019 |
| Project end | September 18, 2025 |
| Funding year | 2023 |
| Award (this year) | $2,050,357 |
| NIH project number | 2R44DE029369-02 |
| Project ID | NIH-10761260 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals scheduled to undergo oral surgical procedures, particularly those involving wisdom teeth removal.
✕Less likely to help
Patients who are not undergoing oral surgical procedures or those with contraindications to the study's treatment method may not benefit from this research.
What this research studies
This research focuses on developing a novel, opioid-free method for managing acute pain following oral surgical procedures, such as wisdom tooth extractions. The approach utilizes a specialized adhesive biomaterial that can deliver pain relief medication directly to the affected area, minimizing the need for systemic opioids. By targeting the pain at its source, this method aims to reduce the risk of opioid dependency and improve patient outcomes. The study will assess the effectiveness and safety of this new pain control technique in a clinical setting.
Why it matters
Potential benefit: If successful, this research could significantly reduce the reliance on opioids for pain management after oral surgeries, lowering the risk of addiction and improving recovery experiences for patients.
How similar studies have gone: Other research has shown promise in developing non-opioid pain management strategies, but this specific approach using a targeted drug delivery system is relatively novel.
Where this research is happening
-
Revbio, INC.
Lowell, United States Active
Researchers
- Principal investigator: Jadia, Rahul — Revbio, INC.
- Study coordinator: Jadia, Rahul
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.