A new method to control pain after oral surgery without opioids

A Novel Opioid-Free Targeted Pain Control Method for Acute Post-Operative Localized Pain Related to Oral Surgical Procedures

NIH-funded research Revbio, INC. · NIH-10761260

This study is testing a new way to help manage pain after dental surgeries, like getting your wisdom teeth out, using a special adhesive that delivers medicine right where it hurts, so you won't need opioids and can feel better safely.

Quick facts

Grant typeSbir 2 grant
Study typeNIH-funded research
Funding institutionRevbio, INC. NIH-funded
Lab location1 site (Lowell, UNITED STATES)
Project IDNIH-10761260 on NIH RePORTER

What this research studies

This research focuses on developing a novel, opioid-free method for managing acute pain following oral surgical procedures, such as wisdom tooth extractions. The approach utilizes a specialized adhesive biomaterial that can deliver pain relief medication directly to the affected area, minimizing the need for systemic opioids. By targeting the pain at its source, this method aims to reduce the risk of opioid dependency and improve patient outcomes. The study will assess the effectiveness and safety of this new pain control technique in a clinical setting.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals scheduled to undergo oral surgical procedures, particularly those involving wisdom teeth removal.

Not a fit: Patients who are not undergoing oral surgical procedures or those with contraindications to the study's treatment method may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could significantly reduce the reliance on opioids for pain management after oral surgeries, lowering the risk of addiction and improving recovery experiences for patients.

How similar studies have performed: Other research has shown promise in developing non-opioid pain management strategies, but this specific approach using a targeted drug delivery system is relatively novel.

Where this research is happening

Lowell, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.