A new method to control gene activity in neurons for studying nerve repair
Official title: An inducible dual up/down gene regulation CRISPR system to study neuronal activity and regeneration
Funded at Stanford University · NIH-11039633 · Data updated 2026-11-12
This study is exploring a new way to help nerve cells heal after injury by using advanced technology to control certain genes in brain cells made from human stem cells, which could lead to better treatments for nerve damage.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $192,500 |
| NIH project number | 1R21NS140949-01 |
| Project ID | NIH-11039633 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that involve nerve damage or degeneration, such as spinal cord injuries or peripheral neuropathies.
✕Less likely to help
Patients with non-neurological conditions or those who do not have any nerve-related injuries may not benefit from this research.
What this research studies
This research focuses on developing a cutting-edge system that can simultaneously activate and repress multiple genes in neurons, which is crucial for understanding how these genes contribute to nerve regeneration after injury. By using human induced pluripotent stem cells that can be turned into neurons, the researchers aim to manipulate specific genes known to influence axon regeneration. This innovative approach utilizes advanced CRISPR technology to provide precise control over gene expression, allowing for a deeper understanding of the genetic interactions involved in neuronal repair.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance nerve regeneration and recovery from neuronal injuries.
How similar studies have gone: Other research has shown promise in using CRISPR technology for gene regulation, indicating that this approach could lead to significant advancements in understanding neuronal regeneration.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Qi, Lei Stanley — Stanford University
- Study coordinator: Qi, Lei Stanley
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.