A new method to capture neuron structures during action potentials
Electrified cryo-EM: a new tool to capture metastable neuron structures during an action potential
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-10910505
This study is testing a new imaging method that helps scientists see how brain cells work when they send signals, which could lead to better treatments for conditions affecting the brain and nervous system.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-10910505 on ClinicalTrials.gov |
What this research studies
This research aims to develop a groundbreaking imaging technique called electrified cryo-electron microscopy (eCryo-EM) that can capture the dynamic structures of neurons during action potentials. By applying an electrical stimulus before rapidly freezing biological samples, the researchers hope to preserve the transient states of neurons that are typically lost in traditional imaging methods. This innovative approach could provide critical insights into how neurons communicate and function in real-time, potentially leading to advancements in understanding various neurological conditions. The research will explore the implications of these findings for medical applications such as drug delivery and wound healing.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions affecting neuronal function, such as epilepsy or other neurological disorders.
Not a fit: Patients with non-neurological conditions or those who do not have any issues related to neuronal activity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to significant advancements in our understanding of neuronal function and the development of new treatments for neurological disorders.
How similar studies have performed: While the approach of using electrified cryo-EM is novel, similar imaging techniques have shown promise in advancing our understanding of biological systems.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LI, YUZHANG — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: LI, YUZHANG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.