A new method to analyze tumor tissue for better cancer understanding.
Official title: A novel multimodal ECM analysis platform for tumor characterization combining morphological and spectrochemical tissue imaging approaches.
Funded at University of Wisconsin-Madison · NIH-10894280 · Data updated 2026-11-12
This study is looking at how the environment around tumors in different types of cancer changes as they grow, using special imaging techniques to see tiny details that can help us understand how cancer develops and how it responds to treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $197,983 |
| NIH project number | 5R61CA281795-02 |
| Project ID | NIH-10894280 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with epithelial cancers, such as breast, pancreatic, or ovarian cancer.
✕Less likely to help
Patients with non-epithelial cancers or those without significant tumor tissue may not benefit from this research.
What this research studies
This research focuses on understanding the tumor microenvironment in various epithelial cancers, particularly by examining changes in the extracellular matrix (ECM) that occur during tumor development. Using advanced imaging techniques, the study aims to combine two methods: Second Harmonic Generation (SHG) optical microscopy and surface enhanced mid-infrared spectral imaging (SE-MIRSI). This approach will allow researchers to analyze both the structural and chemical changes in tumor tissues, which are often too small to be detected by traditional imaging methods. By correlating these findings, the research seeks to provide insights into cancer progression and treatment responses.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and treatment strategies for patients with various types of cancer.
How similar studies have gone: Previous research has shown promise in using advanced imaging techniques for tumor characterization, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Campagnola, Paul J — University of Wisconsin-Madison
- Study coordinator: Campagnola, Paul J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.