A new method to analyze the structure of chromosomes at a single-molecule level
Official title: Proximity Copy Paste: A methodology for single-molecule analysis of chromosome structure
Funded at Sloan-Kettering Inst Can Research · NIH-10779492 · Data updated 2026-11-12
This study is exploring a new way to look closely at how our chromosomes are structured and organized, which could help us understand important processes in our genes and lead to better treatments for genetic conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 30, 2024 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $528,000 |
| NIH project number | 1R01GM152916-01 |
| Project ID | NIH-10779492 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic conditions or those interested in the underlying mechanisms of chromosome structure and function.
✕Less likely to help
Patients with conditions unrelated to chromosomal abnormalities or those not interested in genetic research may not receive direct benefits from this research.
What this research studies
This research focuses on developing a novel methodology called Proximity Copy Paste, which allows for detailed analysis of chromosome structure and organization. By utilizing a proximity labeling approach, the researchers aim to map the folding and protein occupancy of entire chromosomes with high precision. This method can provide insights into how genomic information is accessed, copied, and repaired, which is crucial for understanding various biological processes. Patients may benefit from the findings as they could lead to advancements in genetic research and therapies.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of chromosome behavior, potentially leading to improved treatments for genetic disorders.
How similar studies have gone: Other research has shown promise in using advanced genomic assays for chromosome analysis, indicating that this approach could build on existing knowledge.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Whitehouse, Iestyn — Sloan-Kettering Inst Can Research
- Study coordinator: Whitehouse, Iestyn
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.