A new method to analyze the spatial organization of tumor cells and their interactions.
Official title: A platform for multi-modal single nucleus spatial genomics for molecular tumor analysis
Funded at Broad Institute, INC. · NIH-10918766 · Data updated 2026-11-12
This study is looking at how different cells in tumors work together and how that affects cancer growth and treatment, using a new technology to better understand the tumor environment, which could help doctors create more personalized treatments for cancer patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $417,586 |
| NIH project number | 1R33CA291199-01 |
| Project ID | NIH-10918766 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with various types of tumors who are undergoing treatment or have recently been diagnosed.
✕Less likely to help
Patients with non-cancerous conditions or those who do not have tumor samples available for analysis may not benefit from this research.
What this research studies
This research focuses on understanding how different types of cells within tumors interact and how these interactions influence cancer progression and treatment responses. By using a novel technology called Slide-tags, researchers will analyze tumor samples to map the spatial arrangement of cells and their molecular characteristics. This approach aims to provide insights into the tumor microenvironment, which could lead to more precise diagnostics and targeted therapies for cancer patients.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer diagnostics and more effective treatment strategies tailored to individual tumor environments.
How similar studies have gone: Other research has shown promise in using spatial genomics technologies to enhance our understanding of tumor biology, indicating that this approach could be a significant advancement in cancer research.
Where this research is happening
-
Broad Institute, INC.
Cambridge, United States Active
Researchers
- Principal investigator: Chen, Fei — Broad Institute, INC.
- Study coordinator: Chen, Fei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.