A new method to analyze proteins in the body more effectively
A universal multiplexing approach to unlock the hidden proteome
This study is looking at new ways to find more proteins in biological samples, which could help doctors get better information for diagnosing and treating patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10478967 on NIH RePORTER |
What this research studies
This research focuses on improving the detection of proteins in biological samples using advanced mass spectrometry techniques. By exploring alternative proteases beyond the commonly used trypsin, the study aims to uncover a broader range of proteins that are often missed in traditional analyses. The approach utilizes innovative data-independent acquisition methods to analyze complex protein samples, potentially leading to a more comprehensive understanding of the proteome. Patients may benefit from enhanced diagnostic capabilities and personalized treatment options based on a more complete protein profile.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that may be influenced by protein expression and function, such as cancer or metabolic disorders.
Not a fit: Patients with conditions unrelated to protein abnormalities or those who do not have access to advanced proteomic analysis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and targeted therapies for various diseases by revealing previously hidden proteins.
How similar studies have performed: Other research has shown promise in using alternative proteases and advanced mass spectrometry techniques to enhance protein detection, indicating a potential for success in this novel approach.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Swaney, Danielle L — University of California, San Francisco
- Study coordinator: Swaney, Danielle L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.