A new method for quickly diagnosing bacterial infections in the bloodstream.
Official title: Integrated genotype-informed single-cell molecular antibacterial susceptibility testing platform for rapid and actionable diagnosis of bacteremia
Funded at Johns Hopkins University · NIH-11021010 · Data updated 2026-11-12
This study is working on a fast and easy way to find out if you have bacteria in your blood, which can cause serious infections, so that you can get the right treatment much quicker than with current methods.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | February 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $729,704 |
| NIH project number | 5R01AI183336-02 |
| Project ID | NIH-11021010 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients suspected of having bacteremia or severe bacterial infections.
✕Less likely to help
Patients with non-bacterial infections or those who do not present with symptoms of bacteremia may not benefit from this research.
What this research studies
This research focuses on developing a rapid diagnostic platform for bacteremia, which is the presence of bacteria in the blood that can lead to severe infections like sepsis. Current methods, such as blood cultures, are slow and can take up to five days, during which patients may receive ineffective treatments. The new approach aims to quickly identify the type of bacteria and test their resistance to antibiotics, allowing for timely and appropriate treatment. This integrated platform will enhance the speed and accuracy of diagnosing bacterial infections, ultimately improving patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to faster and more effective treatments for patients with bacterial infections in the bloodstream.
How similar studies have gone: Previous research has shown promise in molecular diagnostics for bacterial infections, but this integrated approach is novel and aims to address existing limitations.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Wang, Tza-Huei Jeff — Johns Hopkins University
- Study coordinator: Wang, Tza-Huei Jeff
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.