A new method for detailed 3D imaging of brain proteins
Official title: A 3D super-resolved platform for rapid and highly multiplexed proteomics
Funded at Panluminate INC. · NIH-11008498 · Data updated 2026-11-12
This study is testing a new technology that helps scientists take super-clear 3D pictures of proteins in brain tissue, which could help us understand brain disorders like Alzheimer's better.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Panluminate INC. NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 16, 2022 |
| Project end | February 28, 2026 |
| Funding year | 2024 |
| Award (this year) | $1,219,907 |
| NIH project number | 2R44MH128999-02 |
| Project ID | NIH-11008498 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neurological conditions, particularly those related to Alzheimer's disease and other brain disorders.
✕Less likely to help
Patients with non-neurological conditions or those not affected by brain disorders may not benefit from this research.
What this research studies
This research focuses on developing a cutting-edge technology called pan-OptiX S3D, which combines advanced microscopy techniques to create highly detailed 3D images of proteins in brain tissue. By using this method, researchers aim to overcome current limitations in imaging resolution and sample degradation, allowing for better mapping of cellular markers in the brain. The approach involves expanding tissue samples and labeling proteins without damaging them, enabling a clearer view of neural networks and brain disorders. This could lead to a deeper understanding of conditions like Alzheimer's disease and other brain disorders.
Why it matters
Potential benefit: If successful, this research could significantly enhance our understanding of brain diseases and improve diagnostic and therapeutic strategies.
How similar studies have gone: Previous research has shown promise in using advanced imaging techniques for studying brain disorders, indicating that this approach could yield valuable insights.
Where this research is happening
-
Panluminate INC.
New Haven, United States Active
Researchers
- Principal investigator: M'saad, Ons — Panluminate INC.
- Study coordinator: M'saad, Ons
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.