A new method for delivering biomolecules directly into cells
Official title: Guided Intracellular Delivery using Precise Area Introduction and Transfection (PAINT)
Funded at Georgia Institute of Technology · NIH-10938834 · Data updated 2026-11-12
This study is testing a new method called PAINT that helps deliver important molecules like DNA or proteins directly into specific cells, which could lead to better treatments for patients needing precise cellular therapies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgia Institute of Technology NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | September 25, 2024 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $488,753 |
| NIH project number | 1R01GM154933-01 |
| Project ID | NIH-10938834 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals with conditions that could benefit from targeted cellular therapies, such as genetic disorders or cancers.
✕Less likely to help
Patients who do not have conditions requiring cellular modification or those who are not candidates for biomolecule therapies may not benefit from this research.
What this research studies
This research focuses on developing a technique called PAINT (Precise Area Introduction and Transfection) that allows for the targeted delivery of biomolecules into specific cells. By using a specialized device, researchers aim to precisely control how and where these biomolecules, such as DNA or proteins, are introduced into cells. This method seeks to overcome the limitations of current delivery techniques, which often lack precision and versatility. Patients may benefit from advancements in therapies that rely on effective cellular modification.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for various diseases by improving how therapies are delivered at the cellular level.
How similar studies have gone: While the approach of precise biomolecule delivery is innovative, similar techniques have shown promise in preliminary studies, indicating potential for success.
Where this research is happening
-
Georgia Institute of Technology
Atlanta, United States Active
Researchers
- Principal investigator: Fedorov, Andrei G — Georgia Institute of Technology
- Study coordinator: Fedorov, Andrei G
Related research
Other NIH-funded projects on the same topics.
-
Integrative AI tools to map protein sequences to structures and functions
A scientist team will develop advanced AI methods to better connect protein sequences, their 3D shapes, and how they work, using large biological data from sequencing and structures.
-
Robotic ultrasound-guided clot removal for stroke treatment
A new robot-assisted ultrasound system is being developed to help quickly reopen brain arteries during a stroke, with testing in patient-specific 3D-printed models and animal studies.
-
siRNA nanoparticle treatment to stop diabetic kidney damage
A new nanoparticle-delivered gene-silencing treatment aims to lower kidney inflammation in people with diabetes to help protect their kidneys.
-
Nanosensor blood test to spot early pancreatic cancer fingerprints
This project will use a nanosensor blood test to detect early-stage pancreatic cancer by reading a disease 'fingerprint' in patient serum.
-
Synergistic blood-brain barrier opening and targeted glioma treatment with pulsed electric fields
A new approach uses tiny, rapid electric pulses to safely disrupt the brain's protective barrier and enhance targeted treatment for malignant glioma.
-
Dexterous needle ablation for ventricular arrhythmia guided by MRI
A new MRI-guided, robot-assisted catheter delivers deeper heart tissue ablation to treat ventricular tachycardia.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.