A new method for analyzing gene expression in single cells.
Official title: TempO-LINC high throughput high sensitivity single cell gene expression profiling assay Ph II
Funded at Biospyder Technologies, INC. · NIH-10873828 · Data updated 2026-11-12
This study is working on a new, easier way to look at how genes are expressed in individual cells, which could help scientists better understand how different cells react to treatments and improve our knowledge of various health conditions.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Biospyder Technologies, INC. NIH-funded |
| Lab location | 1 site (Carlsbad, United States) |
| Project start | June 22, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $1,258,636 |
| NIH project number | 5R44GM140771-03 |
| Project ID | NIH-10873828 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that require detailed cellular analysis to understand treatment responses.
✕Less likely to help
Patients who do not have conditions that involve significant cellular changes or require gene expression profiling may not benefit from this research.
What this research studies
This research focuses on developing a high-throughput and sensitive assay for single-cell gene expression profiling. It aims to overcome limitations of current methods that are costly and inefficient, particularly in measuring low-expressed genes. By using a novel combinatorial approach, the TempO-LINC method allows for the identification of functional cell subtypes and their responses to treatments across large sample sizes. This could significantly enhance our understanding of cellular behavior in various conditions.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and efficient identification of biomarkers and therapeutic responses in patients.
How similar studies have gone: Other research has shown promise with similar high-throughput single-cell analysis methods, indicating potential for success in this novel approach.
Where this research is happening
-
Biospyder Technologies, INC.
Carlsbad, United States Active
Researchers
- Principal investigator: Seligmann, Bruce E. — Biospyder Technologies, INC.
- Study coordinator: Seligmann, Bruce E.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.