A New Medicine to Reduce Liver Cholesterol and Fat Production
Inhibition of hepatic (V)LDL production by a novel antagonist of carboxyl esterase 1
This research explores new medicines that could help your liver make less cholesterol and fat, offering a fresh approach for conditions like high cholesterol and fatty liver disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project ID | NIH-11161408 on NIH RePORTER |
What this research studies
Our scientists found new small molecules using special human liver cells grown in the lab. These molecules are very good at reducing the liver's production of a protein called APOB, which is involved in making cholesterol and fat. Unlike current medicines, these new compounds work in a unique way and don't seem to cause unwanted fat buildup. We are now working to understand exactly how these compounds work by focusing on a specific protein in the liver called CES1. This will help us confirm their effectiveness and prepare them for future testing.
Who could benefit from this research
Good fit: This research is ultimately aimed at helping people who have high cholesterol or fatty liver disease.
Not a fit: Patients seeking immediate treatment or direct participation in a clinical trial would not directly benefit from this early-stage laboratory research.
Why it matters
Potential benefit: If successful, this work could lead to a new class of medicines that effectively lower high cholesterol and reduce fat in the liver, potentially improving heart health and liver function.
How similar studies have performed: This approach uses a novel chemical structure and mechanism, distinct from currently available cholesterol-lowering medications.
Where this research is happening
Charleston, United States
- Medical University of South Carolina — Charleston, United States (Active)
Researchers
- Principal investigator: Duncan, Stephen a — Medical University of South Carolina
- Study coordinator: Duncan, Stephen a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.