A new implant to treat vocal fold issues for better communication and swallowing
Official title: Translating a biostimulatory implant for the long-term treatment of glottic insufficiency
Funded at University of Virginia · NIH-10878958 · Data updated 2026-11-12
This study is testing a new implant that helps people with glottic insufficiency, which makes it hard to speak and swallow, by using a special material that works like natural vocal fold tissue to improve their voice and swallowing for a longer time than current treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $632,171 |
| NIH project number | 5R01DC020998-02 |
| Project ID | NIH-10878958 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing glottic insufficiency due to conditions such as vocal fold paralysis, trauma, or surgery.
✕Less likely to help
Patients with glottic insufficiency caused by non-treatable conditions or those who are not candidates for surgical interventions may not benefit from this research.
What this research studies
This research focuses on developing a biostimulatory implant designed to treat glottic insufficiency, a condition that affects the ability to speak and swallow due to issues with the vocal folds. The approach involves creating a novel microporous scaffold that mimics the natural properties of vocal fold tissue, promoting better integration and function without causing inflammation. By using advanced biomaterials, the research aims to provide a long-lasting solution compared to current temporary treatments that only last a few months. Patients may benefit from improved vocal and swallowing functions through this innovative treatment.
Why it matters
Potential benefit: If successful, this research could provide patients with a permanent solution for vocal fold issues, significantly improving their quality of life.
How similar studies have gone: Previous research has shown promise in using biomaterials for vocal fold augmentation, but this specific approach with the new implant is novel and untested.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Daniero, James J. — University of Virginia
- Study coordinator: Daniero, James J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.