A new implant to treat vocal fold issues for better communication and swallowing
Translating a biostimulatory implant for the long-term treatment of glottic insufficiency
This study is testing a new implant that helps people with glottic insufficiency, which makes it hard to speak and swallow, by using a special material that works like natural vocal fold tissue to improve their voice and swallowing for a longer time than current treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10878958 on NIH RePORTER |
What this research studies
This research focuses on developing a biostimulatory implant designed to treat glottic insufficiency, a condition that affects the ability to speak and swallow due to issues with the vocal folds. The approach involves creating a novel microporous scaffold that mimics the natural properties of vocal fold tissue, promoting better integration and function without causing inflammation. By using advanced biomaterials, the research aims to provide a long-lasting solution compared to current temporary treatments that only last a few months. Patients may benefit from improved vocal and swallowing functions through this innovative treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing glottic insufficiency due to conditions such as vocal fold paralysis, trauma, or surgery.
Not a fit: Patients with glottic insufficiency caused by non-treatable conditions or those who are not candidates for surgical interventions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide patients with a permanent solution for vocal fold issues, significantly improving their quality of life.
How similar studies have performed: Previous research has shown promise in using biomaterials for vocal fold augmentation, but this specific approach with the new implant is novel and untested.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Daniero, James J. — University of Virginia
- Study coordinator: Daniero, James J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.