A new implant to deliver medication for airway injuries
Official title: INJECTABLE, TUNABLE CO-DELIVERY THERAPEUTIC IMPLANT TO REDUCE AIRWAY STENOSIS
Funded at University of Cincinnati · NIH-11062484 · Data updated 2026-11-12
This study is testing a new injectable implant that can slowly release medicine to help heal airway injuries, making it easier for patients to recover without needing lots of painful shots.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $240,372 |
| NIH project number | 5R21EB034840-02 |
| Project ID | NIH-11062484 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 who have experienced laryngeal injuries leading to airway stenosis or inflammation.
✕Less likely to help
Patients with non-airway related conditions or those who do not have laryngeal injuries may not benefit from this research.
What this research studies
This research focuses on developing an injectable implant that can deliver glucocorticoids and antimicrobials to treat airway injuries, which often lead to respiratory failure. The implant aims to provide a non-invasive, controlled release of medication over six weeks, reducing the need for multiple painful injections. By targeting the airway inflammation and microbiome, the study seeks to improve treatment outcomes for patients with laryngeal injuries. The approach has shown promising results in preliminary animal models, indicating minimal immune response.
Why it matters
Potential benefit: If successful, this research could significantly reduce the need for multiple surgeries and improve recovery for patients with airway injuries.
How similar studies have gone: While the approach of using injectable implants for drug delivery is not entirely novel, this specific application for airway injuries is innovative and has shown preliminary success in animal models.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Park, Yoonjee — University of Cincinnati
- Study coordinator: Park, Yoonjee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.