A new heart failure treatment approach using a polypill in India
Official title: Heart Failure Polypill in India: A Late-Stage Implementation Strategy
Funded at Washington University · NIH-11223616 · Data updated 2026-11-12
This study is looking at a new, easier way to help people with heart failure in India by creating a single pill that combines several medications, making it simpler for patients to stick to their treatment and hopefully reduce hospital visits and improve their health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | December 9, 2024 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $249,000 |
| NIH project number | 4R00HL157687-03 |
| Project ID | NIH-11223616 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with heart failure with reduced ejection fraction (HFrEF) living in India.
✕Less likely to help
Patients with heart failure who do not have reduced ejection fraction or those outside the age range of 21+ years may not benefit from this research.
What this research studies
This research investigates a simplified treatment strategy for heart failure patients in India by developing a polypill that combines multiple medications into one. The approach aims to improve adherence to guideline-directed medical therapy, which is often underutilized in low- and middle-income countries. The study will involve gathering insights from healthcare professionals and patients through focus groups and consensus meetings, followed by a clinical trial to assess the effectiveness of the polypill in reducing hospitalizations and mortality rates. By streamlining treatment, the research hopes to enhance patient outcomes significantly.
Why it matters
Potential benefit: If successful, this research could lead to improved management of heart failure, reducing hospital visits and mortality rates for patients in India.
How similar studies have gone: Previous research has shown promise in using simplified medication regimens for chronic diseases, suggesting potential success for this novel approach.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Agarwal, Anubha — Washington University
- Study coordinator: Agarwal, Anubha
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.