A new expandable conduit to help repair heart defects in children
An expandable polymeric valved conduit to repair congenital heart disease
['FUNDING_R01'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-10988264
This study is looking at a new type of heart tube that can grow with kids who have congenital heart disease, so they won't need as many surgeries as they get older.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10988264 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a biostable polymeric valved conduit designed to replace the right ventricular outflow tract (RVOT) in children with congenital heart disease. Currently, over 16,000 children in the U.S. require this type of surgery annually, often needing multiple procedures as they grow. The innovative conduit can be expanded through minimally invasive procedures, potentially reducing the need for repeated open-heart surgeries. The research involves testing the mechanical properties of various materials and validating the conduit’s ability to grow with the patient.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old who have congenital heart defects requiring RVOT replacement.
Not a fit: Patients with fully developed hearts or those who do not require RVOT replacement may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the number of surgeries needed for children with heart defects, improving their quality of life.
How similar studies have performed: Similar approaches in bioengineered tissue and expandable implants have shown promise, suggesting potential success for this innovative conduit.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KALFA, DAVID — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: KALFA, DAVID
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.